Effects of dental materials containing multiple ions releasing filler against viabilities of oral biofilms

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462975
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Conservative dentistry
• Research Institution: Kanagawa Dental College
• Principal Investigator: MUKAI Yoshiharu 神奈川歯科大学, 歯学研究科(研究院), 准教授 (40247317)
• Co-Investigator(Kenkyū-buntansha): HAMADA Nobushiro 神奈川歯科大学, 大学院歯学研究科, 教授 (20247315) ; TOMIYAMA Kiyoshi 神奈川歯科大学, 大学院歯学研究科, 講師 (90237131)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: バイオフィルム / S-PRGフィラー / 脱灰抑制 / 抗菌効果

Outline of Final Research Achievements

It was reported that Surface Pre-Reacted Glass ionomer (S-PRG) filler released multiple ions such as fluoride, strontium and boron, and contributed to inhibit demineralization, as well as it may have antimicrobial effects on oral bacteria.
In this study, we could demonstrated that culture medium containing S-PRG eluate showed predominant antibacterial effects on polymicrobial biofilm model which contained multiple species of oral bacteria in compared with culure medium with NaF. Futher, sixty-minutes' application of the S-PRG eluate on formed polymicrobial biofilms showed also remarkable antibacterial effects.
These results indicate that the S-PRG eluate will be useful for oral health by using delivery systems such as tray-technique.

Free Research Field

保存修復学