Development of noninvasive in vivo hard tissue imaging system using photoacoustic microscope

2015 Fiscal Year Final Research Report

• Project/Area Number: 25462982
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Tohoku University
• Principal Investigator: Hatori Kouki 東北大学, 歯学研究科(研究院), 助教 (40372320)
• Co-Investigator(Kenkyū-buntansha): SAIJO Yoshifumi 東北大学, 大学院医工学研究科, 教授 (00292277) ; SASAKI Keiichi 東北大学, 大学院歯学研究科, 教授 (30178644) ; HAGIWARA Yoshihiro 東北大学, 大学院医学系研究科, 准教授 (90436139)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 光音響顕微鏡 / 光音響効果 / 硬組織イメージング / 非侵襲 / in vivo / 血液循環 / 組織弾性

Outline of Final Research Achievements

Male Wistar rats of 20-week-old (n=5) were used in this study. Mandibles were resected and fixed. Mandibular condylar cartilage was observed with photoacoustic microscopy (PAS). PAS visualized the lesion from subchondral bone to cancellous bone. Ultrasound microscopy visualized the whole cartilage lesion. Thus PAS could visualized the 3-dimentional color image of from cartilage to cancellous bone.
Male Wistar rats of 16-week-old (n=5) were used in this study. Right three molars of maxilla were extracted. After 4 weeks of extraction, both masseter muscles were resected and fixed. Masseter muscle was observed with PAS. Photoacoustic signal was lower in extracted side than in non-extracted side. Ultrasound signal was higher in non^extracted side than in non-extracted side.

Free Research Field

歯科補綴学