Development of the diagnostic method using maxilla/mandibular bone marrow stromal cells for alveolar ridge augmentation

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463007
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Prosthodontics/ Dental materials science and
• Research Institution: Kagoshima University (2014-2015); Nagasaki University (2013)
• Principal Investigator: SUEHIRO FUMIO 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (40524781)
• Co-Investigator(Kenkyū-buntansha): NISHIMURA MASAHIRO 鹿児島大学, 医歯学域歯学系, 教授 (00294570)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 歯槽骨再生 / 顎骨骨髄由来間質細胞 / 転写因子

Outline of Final Research Achievements

On a different condition in the previous study, we selected new nine transcription factors as a candidate of the osteogenic marker of the maxilla/mandibular bone marrow stromal cell (BMSCs). Knockdown of some transcription factors by the small interfering RNAs (siRNAs) resulted in promotion of osteogenesis, and other knockdown resulted in suppression of osteogenesis. Several transcription factors selected in this study have been already reported concerning with in vivo osteogenesis. Thus, these transcription factors which we selected might be reliable prognostic marker for osteogenic potential of BMSCs.

Free Research Field

医歯薬学