2015 Fiscal Year Final Research Report
Development of novel therapy for type 2 diabetes induced xerostomia
| Project/Area Number |
25463011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Prosthodontics/ Dental materials science and
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
Kondo Yusuke 九州歯科大学, 歯学部, 助教 (00611287)
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| Co-Investigator(Kenkyū-buntansha) |
MUKAIBO TARO 九州歯科大学, 歯学部, 助教 (50635117)
HOSOKAWA RYUJI 九州歯科大学, 歯学部, 教授 (60211546)
MASAKI CHIHIRO 九州歯科大学, 歯学部, 准教授 (60397940)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 口腔乾燥症 / 糖尿病 |
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| Outline of Final Research Achievements |
Xerostomia has been reported to be closely associated with diabetes. We have analyzed salivary gland function in KK-Ay, a diabetes mouse model, to explore how diabetes induces xerostomia.
Ca+ release from endoplasmic reticulum was significantly less in KK-Ay than control, which might result in decreased salivary secretion from KK-Ay submandibular gland. result in a decreased concentrations of Na+ and Cl- in the secreted saliva.
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| Free Research Field |
歯科補綴学
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