Long-term stability of bone regenerated by iPS cells in dental implant treatment

2016 Fiscal Year Final Research Report

• Project/Area Number: 25463064
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Fukuoka Dental College
• Principal Investigator: Kido Hirofumi 福岡歯科大学, 口腔歯学部, 教授 (90169897)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: iPS細胞 / 再生骨 / インプラント / 安定性

Outline of Final Research Achievements

We investigated whether autophagy regulate an induction of osteogenesis in mouse iPS cells. Mouse iPS cells (iPS-MED-Ng-20D-17) were used in this study and cultured in the basal medium with leukemia inhibitory factor (LIF). To examine an effect of autophagy to maintain undifferentiated state of iPS cells, the cells were cultured in complete medium with 3-methyladenin (3-MA), autophagy inhibitor.
In the results of this study, autophagy up-regulates the early differentiation in iPS cells. In contrast, autophagy suppresses the osteogenic differentiation in them.

Free Research Field

歯科インプラント