The establishment of photodynamic therapy(PDT) using 5-aminolevulinic acid (ALA) to the oral lichen planus

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463079
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: Masumoto Kazuma 浜松医科大学, 医学部附属病院, 講師 (50464136)
• Co-Investigator(Kenkyū-buntansha): MORIMOTO YUJI 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (10449069) ; KATOU FUMINORI 浜松医科大学, 医学部, 教授 (60204492) ; NAGATA TETSUJI 浜松医科大学, 医学部附属病院, 講師 (60264058)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 口腔扁平苔癬 / ５－アミノレブリン酸 / 光線力学療法

Outline of Final Research Achievements

The aim of this study was establishment of photodynamic therapy(PDT) using 5-aminolevulinic acid (ALA) to the oral lichen planus. Transpiration by CO2 laser was enforced as control study.　At ALA-PDT, local anesthesia was unnecessary, and although the postoperative pain was slight, there were many recurrence cases. The transpiration by CO2 laser required local anesthesia, and postoperative pain was slightly strong. However, most cases were cured completely. For this reason, when complete response rate was taken into consideration, transpiration by CO2 was superior to ALA-PDT.

Free Research Field

歯科口腔外科学