Favorable anesthetics based on postoperative vascular endothelial function and finger photoplethysmogram indices

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463140
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kagoshima University
• Principal Investigator: Kohjitani Atsushi 鹿児島大学, 医歯学域歯学系, 准教授 (60304325)
• Co-Investigator(Kenkyū-buntansha): 大野 幸 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (00535693) ; 遠矢 明菜 鹿児島大学, 医歯学域医学部・歯学部附属病院, 助教 (80593649) ; 山下 薫 鹿児島大学, 医学部・歯学部附属病院, 医員 (50762613)
• Co-Investigator(Renkei-kenkyūsha): Miyata Masaaki 鹿児島大学, 医歯学域医学系, 准教授 (00347113) ; Hashiguchi Teruto 鹿児島大学, 医歯学域医学系, 教授 (70250917)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 血管内皮機能 / 全身麻酔 / 指尖容積脈波 / 心血管イベントリスク / プロポフォール / セボフルラン / 酸化ストレス / Reactive hyperemia index

Outline of Final Research Achievements

Endothelial dysfunction is observed in several cardiovascular diseases, where endothelium-dependent vasodilation is impaired by oxidative stress. Endothelial function of the brachial artery is useful to estimate future risk of cardiovascular events. The purpose of this study is to investigate the time-course of endothelial function during the perioperative period of moderate surgery, and factors affecting recovery of endothelial function. Endothelial function was evaluated by reactive hyperemia index (RHI), which is a ratio of reactive hyperemia-stimulated vasodilation to that measured without stimulation using the EndoPAT 2000. Endothelial function was suppressed just after surgery, which took a few days returning to control levels. Recovery of endothelial function was impaired by diabetes mellitus, obesity and hyperuricemia.

Free Research Field

歯科麻酔学