Involvement of medullary GABAergic system in extraterritorial neuropathic pain mechanisms associated with inferior alveolar nerve transection.

2015 Fiscal Year Final Research Report

• Project/Area Number: 25463151
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Nihon University
• Principal Investigator: OKADA-OGAWA Akiko 日本大学, 歯学部, 准教授 (10434078)
• Co-Investigator(Kenkyū-buntansha): IWATA Kouichi 日本大学, 歯学部, 教授 (60160115) ; SHINODA Masamichi 日本大学, 歯学部, 准教授 (20362238) ; IMAMURA Yoshiki 日本大学, 歯学部, 教授 (90176503)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 神経障害性疼痛 / GABA / KCC2 / 三叉神経障害 / 脊髄路核

Outline of Final Research Achievements

Involvement of the functional changes in the GABAergic system in the trigeminal spinal subnucleus caudalis (Vc) in the mechanisms underlying extraterritorial neuropathic pain in the orofacial region following inferior alveolar nerve transection (IANX) is investigated. It was revealed that GABAergic Vc neurons might be reduced in their number at the early period after IANX and the functional changes might occur in GABAergic neurons from inhibitory to excitatory at the late period after IANX, suggesting that the neuroplastic changes occur in the GABAergic neuronal network in the Vc due to morphological and functional changes at different time periods following IANX and resulting in the extraterritorial neuropathic pain in the orofacial region following trigeminal nerve injury.

Free Research Field

麻酔学