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2016 Fiscal Year Final Research Report

Elucidation of epigenetic mechanism in gingival epithelium by periodontal pathogen

Research Project

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Project/Area Number 25463223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Periodontology
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

Michiko Nishimura  北海道医療大学, 歯学部, 講師 (10337040)

Project Period (FY) 2013-04-01 – 2017-03-31
Keywordsエピジェネティクス / 歯周疾患 / 線維芽細胞 / DNAメチル化 / LPS / 歯周病原菌 / 歯周組織
Outline of Final Research Achievements

In this study, we investigated epigenetics change when P. gingivalis-derived LPS was allowed to act on human gingival fibroblasts for a long time. LPS chronic stimulation was given to human gingival fibroblasts, DNA hypermethylation and mRNA expression decrease of fibronectin type III (FN), αI (XII) collagen (XII-collagen) and extracellular matrix protein related genes were observed . Protein analysis also reduced the expression of XII-collagen and FN and its expression was restored by demethylating agent.These result suggest that periodontal pathogen-derived LPS is involved in the pathogenesis and progression of periodontal disease due to gene expression reduction through epigenetic modification.

Free Research Field

臨床口腔病理

URL: 

Published: 2018-03-22  

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