The Effects of Periodontal Disease as a Risk for Preterm Birth and Low Birth-Weight Infants in Women with Gestational Diabetes Mellitus.

2016 Fiscal Year Final Research Report

• Project/Area Number: 25463227
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Periodontology
• Research Institution: Showa University
• Principal Investigator: Koide Yoko 昭和大学, 歯学部, 助教 (40407466)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Matsuo 昭和大学, 歯学部, 教授 (50332896) ; OKAMATSU Yoshimasa 昭和大学, 歯学部, 助教 (50286845) ; KOIDE Keiko 昭和大学, 医学部, 講師 (90384437)
• Research Collaborator: OSAMURA Anna 昭和大学, 医学部, 講師 ; KOHASHI Kyoko 昭和大学, 医学部, 助教 ; TOMOYASU Masako 昭和大学, 医学部, 助教 ; OBA Tomohiro 昭和大学, 医学部, 助教
• Project Period (FY): 2013-04-01 – 2017-03-31
• Keywords: 歯周病 / 妊娠糖尿病 / 早産 / 低体重児出産

Outline of Final Research Achievements

There have been many studies about periodontal medicine. However, there have been little studies about the association between periodontitis and preterm low birth-weight infants in women with gestational diabetes. The purpose of this prospective cohort study is to investigate whether periodontal disease is risk factors of the preterm low birth-weight infants in Japanese women with gestational diabetes. In the present finding, 15% of subjects gave birth to low weight infant, and none was preterm birth. The values of serum cholesterol elevated over normal range among many subjects. The weakness of this study was that the sample size was small. Therefore, the present findings were unable to suggest that there were relationship between periodontitis and preterm birth, low birth-weight infants, and obesity in subjects. Additional study with sufficient sample size may be needed to assess the relationship between periodontitis and adverse pregnancy outcome.

Free Research Field

歯周病学