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2015 Fiscal Year Final Research Report

Mouth washes containing zinc ion to inhibit oral malodor

Research Project

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Project/Area Number 25463264
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Social dentistry
Research InstitutionNihon University

Principal Investigator

NAKANO Yoshio  日本大学, 歯学部, 准教授 (80253459)

Co-Investigator(Kenkyū-buntansha) TANIGUCHI Nao  福岡歯科大学, 口腔歯学部, 准教授 (60372885)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords亜鉛 / 口臭 / 口腔内細菌叢
Outline of Final Research Achievements

Zinc ions bind to volatile sulfur compounds, reducing oral malodor, and have effects on several oral microorganisms. This study investigated changes in oral microbiota after treatment with a mouth rinse containing zinc chloride. Bacterial 16S ribosomal RNA genes were amplified from the samples, and their nucleotide sequences were determined using barcoded pyrosequencing analysis. The abundance of Porphyromonas sp., Fusobacterium periodonticum, Gemella haemolysans, Haemophilus parainfluenzae, and Streptococcus gordonii significantly decreased after treatment with zinc chloride. Porphyromonas sp. and Fusobacterium sp. are organisms involved in oral malodor. The abundance of Rothia sp., Actinomyces sp. and Streptococcus sp. significantly increased, and were predominant in the oral microbiota. These results suggest that zinc ions inhibit the growth of specific species including oral malodor-related organisms, without altering the entire bacterial ecology.

Free Research Field

予防歯科学

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Published: 2017-05-10  

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