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2015 Fiscal Year Final Research Report

Identification and functional analysis of food ingredients derived from regional goodies by in vivo imaging technique

Research Project

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Project/Area Number 25504010
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Integrated Nutrition Science
Research InstitutionWakayama Medical University

Principal Investigator

IHARA HAYATO  和歌山県立医科大学, 共同利用施設, 講師 (00223298)

Co-Investigator(Kenkyū-buntansha) AKAMIZU Takashi  和歌山県立医科大学, 医学部, 教授 (20231813)
KISHIDA Kunihiro  近畿大学, 生物理工学部, 講師 (30412703)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywords抗肥満効果 / 機能性食品成分 / 生体イメージング
Outline of Final Research Achievements

1. Examined the effects of hydroxycinnamic acids on gene expression of adipokines in 3T3-L1 adipocytes. . Among them, caffeic acid significantly reduced resistin, which causes insulin resistance state, gene expression dose dependently. In addition, caffeic acid also reduced resistin-reporter gene expression in stable adipocytes. After transplantation of these stable cells into inguinal fat pads of nude mice, administration of caffeic acid also reduced the reporter-gene expression in vivo.
2. We have examined effects of an another compound (patent pending) derived from regional goodies on high fat diet (HFD)-induced weight gain. C57BL/6 mice fed an HFD with this compound (3% w/w) significantly leaded to a reduced weight gain only after 1-week period compared with HFD-fed mice, and leaded to an induction of UCP-1 gene expression in inguinal fat pads.

Free Research Field

分子病態生理学、脂肪細胞の分子イメージング

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Published: 2017-05-10  

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