ヒトの関節炎と睡眠障害の研究

2014 Fiscal Year Research-status Report

• Project/Area Number: 25515003
• Research Institution: Kyushu University
• Principal Investigator: 塩沢 俊一 九州大学, 大学病院, 教授 (40154166)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 概日リズム / 疾患活動性 / 日常生活動作

Outline of Annual Research Achievements

研究①すなわち生物学的製剤の治療介入前後を通じて、患者の疾患活動性の変化および睡眠障害への効果にかかる検証については、現在、１５０例の調査が終了した。
研究②すなわち夜のホルモンであるメラトニン作動薬ラメルテオインによる概日リズム是正効果の研究：睡眠障害の改善が患者の日常生活動作及び疾患活動性に及ぼす治療効果の検証の課題については、現在は、前回の3例に加え7例計10例の患者さんに検証を済ませた。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

研究①は目標を達成しこれを超えて継続している。
研究②はほぼ目標に近くなり現在継続している。

Strategy for Future Research Activity

研究②の組み入れを追加し、研究①②総合して結果解析に移る。

Causes of Carryover

平成27年度に使用見込みがあるため。

Expenditure Plan for Carryover Budget

最終年度であるため学会発表および臨床試薬の購入等を予定している。

Research Products

• [Journal Article] The impact of c-Fos/Activator protein-1 inhibition on allogeneic pancreatic islet transplantation. (2015)
  • Author(s): Yoshida T, Yamashita K, Watanabe M, Koshizuka Y, Kuraya D, Ogura M, Asahi Y, Ono H, Emoto S, Mizukami T, Kobayashi N, Shibasaki S, Tomaru U, Kamachi H, Matsushita M, Shiozawa S, Hirono S, Todo S.
  • Journal Title: Am J Transplantation Volume: in press Pages: in press
  • DOI: in press
  • Peer Reviewed / Open Access
• [Journal Article] Anti-carbamylated protein antibodies in rheumatoid arthritis patients of Asian descent. (2015)
  • Author(s): Verheul MK, Shiozawa K, Levarht EWN, Huizinga TWJ, Toes REM, Trouw LA, Shiozawa S.
  • Journal Title: Rheumatology Volume: in press Pages: in press
  • DOI: in press
  • Peer Reviewed / Open Access
• [Journal Article] In vivo cell transfer assay to detect autoreactive T cell subsets. (2014)
  • Author(s): Miyazaki Y, Shiozawa S.
  • Journal Title: Methods Mol Biol Volume: 1142 Pages: 49-53
  • DOI: 10.1007/978-1-4939-0404-4_6.
  • Peer Reviewed / Open Access
• [Journal Article] Studies on the T cell receptor (TCR) revision of autoantibody-inducing CD4 T (aiCD4 T) cell. (2014)
  • Author(s): Shiozawa S, Uto K.
  • Journal Title: Methods Mol Biol Volume: 1142 Pages: 65-73
  • DOI: 10.1007/978-1-4939-0404-4_8.
  • Peer Reviewed / Open Access
• [Journal Article] Induction of de novo autoimmune disease in normal mice upon repeated immunization with antigen. (2014)
  • Author(s): Tsumiyama K, Shiozawa S.
  • Journal Title: Methods Mol Biol Volume: 1142 Pages: 85-90
  • DOI: 10.1007/978-1-4939-0404-4_10.
  • Peer Reviewed / Open Access
• [Presentation] Specifying the autoantibody-inducing CD4 T cell (aiCD4 T cell) causing systemic lupus erythematosus (SLE) out of PD-1+CD45RBlo122lo CD4 subpopulation using mass spectrometry. (2015)
  • Author(s): Shiozawa S, Miyazaki Y, Tsumiyama K.
  • Organizer: Immunology 2015 (102th Annual Meeting of AAIS)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2015-05-08 – 2015-05-12
• [Presentation] The autoantibody-inducing CD4 T cell (aiCD4 T cell) causing SLE belongs to PD-1+CD45RBlo122lo CD4 subpopulation. (2014)
  • Author(s): Miyazaki Y, Tsumiyama K, Shiozawa S.
  • Organizer: Immunology 2014 (101th Annual Meeting of AAIS)
  • Place of Presentation: Pittsburgh, USA
  • Year and Date: 2014-05-02 – 2014-05-06
• [Presentation] Sec 61 plays an essential role in facilitating antigen cross-presentation. (2014)
  • Author(s): Tsumiyama K, Shiozawa S.
  • Organizer: Immunology 2014 (101th Annual Meeting of AAIS)
  • Place of Presentation: Pittsburg, USA
  • Year and Date: 2014-05-02 – 2014-05-06
• [Book] 膠原病学 第6版 (2015)
  • Author(s): 塩沢俊一
  • Total Pages: 620
  • Publisher: 丸善
• [Book] Methods in Molecular Biology vol 1142 (2014)
  • Author(s): Shiozawa S, eds.
  • Total Pages: 204
  • Publisher: Springer Humana Press