Study on the relationship between arthritis and the quality of sleep

2015 Fiscal Year Final Research Report

• Project/Area Number: 25515003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 睡眠科学
• Research Institution: Kyushu University
• Principal Investigator: Shiozawa Shunichi 九州大学, 大学病院, 学術研究員(特任教授) (40154166)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 関節リウマチ / 睡眠 / 生物学的製剤 / rheumatoid arthritis / sleep / biological DMARDs

Outline of Final Research Achievements

The contribution of inflammation (arthritis) to the quality of sleep and vise versa was studied in the patients with rheumatoid arthritis (RA). We have studied 517 patients with rheumatoid arthritis with biologic DMARDs (tocilizmab 175, abatacept 98, or infliximab 144). Evaluation was made with Pittsburgh score, Epworth score and actigraphy, and the results were compared with arthritic indices. As a result, Pittsburgh score showed presence of sleep disturbance, in which global score showed 6.42±2.76 which was higher than normal level 5, thus indicating the presence of sleep disturbance. Actigraphy showed that %sleep 89.1±10.5, total wake after sleep 49.5±45.2 min, average wake after sleep onset 9.9±23.3times, and these values were abnormal as compared with healthy controls. Further, these values showed a posistive correlation with C-reactive protein levels and swollen joint counts of patients. After biologic DMARDs treatments (n=517), these abnormalities were all normalized.

Free Research Field

内科学、膠原病学