Development of bio-dosimetry methods using radiation responsive urinary biomarker

2014 Fiscal Year Final Research Report

• Project/Area Number: 25550031
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Hiroshima University
• Principal Investigator: KAMIYA Kenji 広島大学, 原爆放射線医科学研究所, 教授 (60116564)
• Co-Investigator(Kenkyū-buntansha): IIZUKA Daisuke 広島大学, 原爆放射線医科学研究所, 助教 (00455388) ; SASATANI Megumi (豊島 めぐみ) 広島大学, 原爆放射線医科学研究所, 助教 (80423052)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 生物影響 / 生物学的線量評価法 / 糖鎖修飾

Outline of Final Research Achievements

The different biological effect of radiation exposure is induced by different radiation doses. From this viewpoint, the rapid, accurate dose estimation is anticipated when radiation accident is occurred. Until now, counting chromosome aberration in peripheral blood lymphocyte is the most accurate method for evaluating exposed dose, but this method is time consuming and requires expert skills. Our final goal is to establish rapid, high-throughput radiation bio-dosimetry/radiation risk assessment method using noninvasive specimen materials. The glycosylation status of mouse urine Adipsin protein was modulated for 8 to 48 h after 0.25 to 6 Gy of radiation exposure. The establishment of radiation bio-dosimetry method using the protein glycosylation status will be expected in the future.

Free Research Field

放射線生物学