Investigation for the mechanism of hypoalgesia after upper limbs exercise for postoperative patients with lower extremity arthritis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560263
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Nagasaki University
• Principal Investigator: OKITA Minoru 長崎大学, 医歯薬学総合研究科(保健学科), 教授 (50244091)
• Co-Investigator(Kenkyū-buntansha): NAKANO Jiro 長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20380834) ; SAKAMOTO Jyunya 長崎大学, 医歯薬学総合研究科(保健学科), 准教授 (20584080) ; MORIMOTO Yosuke 長崎大学, 病院(医学系), 技術職員 (40534409)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 理学療法学 / 運動療法 / 上肢運動 / 運動誘発性疼痛抑制効果 / バイオマーカー

Outline of Final Research Achievements

The objective of this study was to determine the effect of upper limbs exercise for postoperative patients with lower extremity arthritis. An animal experiment and clinical study were performed by this study. Animal models in this study were arthritis-induced pain model and immobilization-induced pain model in rats. Therapeutic intervention for the former model was upper limbs exercise, and it to a latter model was treadmill exercise using non-immobilized limbs. As a result, exercise-induced hypoalgesia confirmed both models. However, upregulation ofβ-endorphin in the brain tissue was admitted only by the latter model. In clinical study, the effect of the combination therapy with arm ergometer exercise and usual physical therapy programs for patients with anterior and posterior cruciate ligament reconstruction was considered. The utility of the combination therapy was not clear and was future's subject of investigation.

Free Research Field

リハビリテーション科学