Roles of skeletal muscle in whole body homeostasis

2015 Fiscal Year Final Research Report

• Project/Area Number: 25560338
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Sports science
• Research Institution: Nagasaki University
• Principal Investigator: ONO Yusuke 長崎大学, 原爆後障害医療研究所, 講師 (60601119)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨格筋 / 生体恒常性 / がんカヘキシア / 筋萎縮 / 筋可塑性 / 筋由来分泌因子

Outline of Final Research Achievements

We examined roles of skeletal muscle in whole body homeostasis using mouse models including cancer cachexia. Cancer cachexia was induced by injection of C26 mouse colon cancer cells. Several genes involved in regulating lipid metabolism in the body were abnormally expressed in atrophic muscles in the cancer cachexia model. We next investigated the function of μ-Crystallin (Crym) in skeletal muscle as well as whole body homeostasis. Crym was preferentially expressed in skeletal muscle. Crym-knockout mice exhibited an increase in grip strength and high intensity running ability. Genetic inactivation of Crym also improved high-fat-diet-induced metabolic abnormalities in vivo. These results indicate that the alteration in quality and mass of muscles potentially influences whole body homeostasis.

Free Research Field

骨格筋生物学