2014 Fiscal Year Final Research Report
Identification of muscle derived immune suppressive factor
Project/Area Number |
25560367
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Applied health science
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Research Institution | Osaka University |
Principal Investigator |
FUKADA So-ichiro 大阪大学, 薬学研究科(研究院), 研究員 (20432445)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | 骨格筋 / 筋傷害 / 炎症性サイトカイン / 筋ジストロフィー |
Outline of Final Research Achievements |
In general, moderate exercise enhances immune system. However, hard exercise, such as a triathlon, is often accompanied by the impairment of immune system. During the time of immune impairment, bacteria or virus are allowed to infect our body easily. In other word, a window is opened for a virus by hard exercise. Therefore, this model is referred to as the open window theory. Using acute and chronic muscle-injured model, we found that muscle regeneration suppresses LPS-mediated inflammatory cytokine expression. We could deny the effect of stress, because stress maker was not increased in these models.
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Free Research Field |
幹細胞生物学
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