2013 Fiscal Year Final Research Report
Molecular genetic analysis of atherosclerosis and atrial thrombosis rat model spontaneously induced by hypoactivity
| Project/Area Number |
25560368
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied health science
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| Research Institution | The University of Tokushima |
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Principal Investigator |
IMOTO Issei (橘 逸勢) 徳島大学, ヘルスバイオサイエンス研究部, 教授 (30258610)
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| Co-Investigator(Renkei-kenkyūsha) |
TAJIMA Atsushi 徳島大学, 大学院・へルスバイオサイエンス研究部, 准教授 (10396864)
NAKAYA Yutaka 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授 (50136222)
NIKAWA Takeshi 徳島大学, 大学院・へルスバイオサイエンス研究部, 教授 (20263824)
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| Project Period (FY) |
2013-04-01 – 2014-03-31
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| Keywords | スポーツ医学 / ゲノム / ラット / 遺伝学 / 高血圧 / 血栓 / エピジェネティックメモリー / 次世代シーケンサー |
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| Research Abstract |
We tried to identify genetic alterations responsible for atherosclerosis and atrial thrombosis with cerebral infarction spontaneously induced by hypoactivity in the SPORTS (Spontaneously Running Tokushima-Shikoku) rat model and molecular mechanisms of preventive effects of exercise on these phenotypes. We modified our self-made rat exon capture system and linkage analysis system, and identified a set of candidate responsible genes using these systems. Genome-wide expression analysis of vascular system also identified candidate genes associated with these phenotypes. In addition, we established systems to determine DNA methylation status and modify genome structure in rats. However, specific gene(s) and molecular mechanisms responsible for those phenotypes were unable to be determined even though using integrated analysis of omics data, suggesting that unknown genomic alterations and/or polygene-environment interactions contribute to acquire these phenotypes in this model.
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Research Products
(12 results)
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[Journal Article] The expression and clinical significance of connective tissue growth factor in advanced head and neck squamous cell cancer2014
Author(s)
Kikuchi R, Kikuchi Y, Tsuda H, Maekawa H, Kozaki KI, Imoto I, Tamai S, Shiotani A, Iwaya K, Sakamoto M, Sekiya T, Matsubara O
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Journal Title
DOI
Peer Reviewed
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[Journal Article] Meta-analyses of blood homocysteine levels for gender and genetic association studies of the MTHFR C677T polymorphism in schizophrenia2014
Author(s)
Nishi A, Numata S, Tajima A, Kinoshita M, Kikuchi K, Shimodera S, Tomotake M, Ohi K, Hashimoto R, Imoto I, Takeda M, Ohmori T
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Journal Title
URL
Peer Reviewed
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[Journal Article] NF-κB inducing kinase, a central signaling 1 component of the non-canonical pathway of NF-κB, contributes to ovarian cancer progression2014
Author(s)
Uno M, Saitoh Y, Mochida K , Tsuruyama E, Kiyono T, Imoto I, Inazawa J, Yuasa Y, Kubota T, Yamaoka S
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Journal Title
PLoS One
Volume: 9(2)
Pages: e88347
DOI
Peer Reviewed
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