Development of photoactivatable molecule using photoreceptor protein and its application

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560403
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biomolecular chemistry
• Research Institution: Osaka University
• Principal Investigator: HORI Yuichiro 大阪大学, 工学(系)研究科(研究院), 助教 (00444563)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 光受容タンパク質 / PYP / 光構造変換

Outline of Final Research Achievements

Caged compounds are useful functional molecules that can control its bioactivity. On the other hand, there are some problems that some of the compounds require UV irradiation or undergoes photodegradation during syntheses. Herein, to overcome these problems, we creat a novel photoconversion system using a photoreceptor protein, PYP, and its newly found ligand, 2,4-dihydroxycinnamic acid. In this system, the ligand binds to PYP and induces photoisomerization and the subsequent structural change upon irradiation with visible light.

Free Research Field

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