Creating Gene Expression Based Digital Brain Atlas with Our New Mapping Technique and Map Analysis

2014 Fiscal Year Final Research Report

• Project/Area Number: 25560428
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Basic / Social brain science
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: OHO Yuko 独立行政法人理化学研究所, 光量子工学研究領域, 客員研究員 (60381571)
• Co-Investigator(Kenkyū-buntansha): YOKOTA Hideo 独立行政法人理化学研究所, 光量子工学研究領域, チームリーダー (00261206)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 遺伝子発現 / ３次元脳地図 / バイオインフォマティクス / データベース / 画像処理 / ネットワーク解析

Outline of Final Research Achievements

We fine-tuned our 3D gene expression mapping technique, Transcriptome Tomography, to create data sets of the mouse brain in developmental stages (3d, 7d 3w and 8w after birth) for overviewing comprehensive gene expression in the whole brain 3D anatomical context. We analyzed the data with atlas informatics, which is a new framework to integrate bioinformatics, such as co-expression analysis, and image processing of MRI or block-face images, and then, we have renewed the database, ViBrism DB, as a neuroscience open resource.

Free Research Field

複合領域