2015 Fiscal Year Final Research Report
Establishment of Gel-Assmbly System with Metalloporphyrins and Ligands towards the Creation of Macroscopic Functions
| Project/Area Number |
25620099
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Polymer chemistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 配位結合 / 金属ポルフィリン / アミノ酸 / 分子認識 / 高分子ヒドロゲル / 接着 / 可逆性 / pH応答性 |
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| Outline of Final Research Achievements |
A gel assembly was formed via metal-ligand interactions using polyacrylamide modified with iron-porphyrin (Fe-Por) and L-histidine (L-His) moieties. The Fe-Por gel and the L-His gel immediately adhere to each other upon agitation in an 80 mM Tris-acetate buffer (pH 9.0). The assembly of the Fe-Por gel with L-His gel showed a pH dependency. The L-His gel formed an assembly with the Fe-Por gel at pH 9.0, however, no assembly of gels was observed at pH 2.0. Agitation in an aqueous solution containing an 60 mM L-His causes the assembly of the Fe-Por gel and L-His gel to dissociate, then washing with a fresh buffer reassembles the gel pieces. The binding and dissociation of the Fe-Por gel with the L-His gel are found to be reversible.
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| Free Research Field |
高分子化学
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