Prediction of Thrombus Development and Antithrombotic Therapy Plan Based on Biomechanics

2014 Fiscal Year Final Research Report

• Project/Area Number: 25630046
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Fluid engineering
• Research Institution: Chiba University
• Principal Investigator: TSUBOTA Ken-ichi 千葉大学, 工学(系)研究科(研究院), 准教授 (10344045)
• Co-Investigator(Renkei-kenkyūsha): LIU Hao 千葉大学, 大学院工学研究科, 教授 (40303698) ; HANEISHI Hideaki 千葉大学, 大学院工学研究科, 教授 (20228521)
• Research Collaborator: SUGHIMOTO Koichi The Royal Children's Hospital, Melbourne, 医師
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: バイオメカニクス / 血流 / 血栓 / 単心室 / 粒子法 / 計算機シミュレーション

Outline of Final Research Achievements

A biomechanics simulation method of thrombus formation in a cardiovascular system was developed considering the influence of blood flow. The atriopulmonary connection (APC) and the total cavopulmonary connection (TCPC) were considered as an operation for single ventricle. As a result of simulation, blood flow and the resulting thrombus formation were different between APC and TCPC. A simulation model of medicinal effects of antithrombotic drug was developed to investigate effects of an amount and administration timing on the antithrombotic. On the other hand, mechanism of motion and deformation of red and white blood cells was investigated toward development of high precision biomechanics model for thrombus formation.

Free Research Field

バイオメカニクス