Invention of nano delivery systems with food antioxidants in the body.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25660094
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Food science
• Research Institution: Tohoku University
• Principal Investigator: MIYAZAWA Teruo 東北大学, (連合)農学研究科(研究院), 教授 (20157639)
• Co-Investigator(Kenkyū-buntansha): NAKAGAWA Kiyotaka 東北大学, 大学院農学研究科, 准教授 (80361145) ; KIMURA Fumiko 東北大学, 大学院農学研究科, 助教 (50321980)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ナノデリバリーシステム / ナノ粒子 / 食品成分 / 抗酸化物質 / 動物実験

Outline of Final Research Achievements

Rise of oxidative stress in the brain is enhanced by the aggregation of amyloid-beta protein and decrease of lipophilic antioxidants. This phenomenon is associated as one factor in the generation of Alzheimer's disease (AD). However, there is no certain treatment or cure for AD. This may be due to the blood brain barrier (BBB), which limits brain uptake of various bioactive compounds (including small molecules). Therefore, in the present study, we prepare the “lipophilic antioxidant encapsulated biodegradable nanoparticles” and challenge to improve brain lipophilic antioxidant concentrations (by decreasing oxidative stress in the brain) by oral intake.

Free Research Field

食品科学