Screening and characterization of factors regulating lifespan in fission yeast

2015 Fiscal Year Final Research Report

• Project/Area Number: 25660290
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied molecular and cellular biology
• Research Institution: Nagoya University
• Principal Investigator: Aiba Hirofumi 名古屋大学, 創薬科学研究科, 教授 (60211687)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 分裂酵母 / 寿命 / 老化

Outline of Final Research Achievements

In this study, we screened and characterized factors affecting chronological lifespan in fission yeast to gain insight how the lifespan of cell is regulated. We have succeeded to identify some novel factors whose recessive mutations result in the elongation of lifespan. Therefore if we could find reagent that inhibits function of the novel factor, we might be able to elongate fission yeast lifespan by treatment with such reagent. We also found genes whose over-expression result in the elongation of lifespan. Here we could accumulate basic knowledge for lifespan regulation of fission yeast.

Free Research Field

微生物学