Understanding and manipulation of microtubule-mediated inflammatory response

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670027
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Osaka University
• Principal Investigator: SAITOH Tatsuya 大阪大学, 微生物病研究所, 准教授 (60456936)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 自然免疫 / 炎症 / サイトカイン / 微小管 / オルガネラ

Outline of Final Research Achievements

Innate immune system is critically involved in induction of inflammatory responses. Innate immune system detects microbial components by pattern-recognition receptors and induces production of inflammatory cytokines. However, innate immune system also senses host-derived stimulatory factors and nutrient components, and often causes development of inflammatory diseases. We have examined a molecular mechanism underlying regulation of innate immune system and have revealed an essential role of microtubules in induction of inflammatory responses.

Free Research Field

生物系薬学