2015 Fiscal Year Final Research Report
Functional analyses of mitochondrial fusion inhibition in the regulation of neuronal cells
| Project/Area Number |
25670038
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KASAI ATSUSHI 大阪大学, 大学院薬学研究科, 助教 (40454649)
BABA AKEMICHI 兵庫医療大学, 学長 (70107100)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | ミトコンドリア / 脳・神経 / 細胞死 / 酸化ストレス / 細胞分化 / 発現制御 / 化合物スクリーニング / ノックアウトマウス |
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| Outline of Final Research Achievements |
Recently, much attention has been gathered on the mitochondrial fusion and division machinery as a novel drug targets for neurodegenerative diseases. In this study, we performed functional analyses of the novel factor MIFI (mitochondrial fusion inhibitor) in the neuronal development and cell death. The obtained results suggested that MIFI functions in the neuronal cells possibly from early development, is associated with oxidative stress status, and shows stimulatory effects in the insult-induced cell death of neuroblastoma SH-SY5Y cells. In addition, this study developed essential research tools for the further functional analyses of MIFI, such as chemical compounds regulating MIFI expression and mice lacking MIFI.
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| Free Research Field |
分子薬理学
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