Development of Protein-Protein Interaction Inhibitors

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670050
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Drug development chemistry
• Research Institution: Hokkaido University
• Principal Investigator: ICHIKAWA SATOSHI 北海道大学, 薬学研究科(研究院), 准教授 (60333621)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: タンパク質タンパク質間相互作用 / 薬物設計 / 有機合成

Outline of Final Research Achievements

It is a quite important issue to develop a strategy for rational design of protein-protein interaction inhibitors (PPIs). In this study, a small library of PPIs with diverse structures was first designed and synthesized. We have found that several compounds inhibit a protein-protein interaction with a moderate activity. A larger set of library was further synthesized.

Free Research Field

創薬化学