2014 Fiscal Year Final Research Report
Exploration of adjuvant for optimization of transcutaneous vaccine
| Project/Area Number |
25670076
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Keywords | ワクチン / アジュバント / マイクロニードル |
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| Outline of Final Research Achievements |
We have developed a dissolving microneedle array for use as a transcutaneous vaccination (TCV) device, and reported that TCV with the dissolving microneedle array induced an immune response against antigens as well as systemic injection. In this study, I searched for the adjuvant which aimed at optimization of TCV. As a result, Monophosphoryl Lipid A (MPLA) and ODN1826 enhanced antibody production against ovalbumin as a model antigen on TCV used dissolving microneedle. ODN1826 and MPLA will be useful as TCV adjuvant.
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| Free Research Field |
生物薬剤学
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