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2015 Fiscal Year Final Research Report

Development of diagnosis and treatment of Parkinson disease at early stage using novel biomarker oxidized DJ-1

Research Project

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Project/Area Number 25670084
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionDoshisha University

Principal Investigator

Yoshiro Saito  同志社大学, 生命医科学部, 准教授 (70357060)

Co-Investigator(Renkei-kenkyūsha) NOGUCHI Noriko  同志社大学, 生命医科学部, 教授 (40198578)
SAIGOH Kazumasa  近畿大学, 医学部, 講師 (50319688)
Project Period (FY) 2013-04-01 – 2016-03-31
Keywordsパーキンソン病 / 酸化ストレス / DJ-1 / バイオマーカー / モノクローナル抗体 / 早期診断 / ELISA / ドパミン神経
Outline of Final Research Achievements

DJ-1, the product of the causative gene of a familial form of Parkinson’s disease (PD), undergoes preferential oxidation at the cysteine residue at position 106 (Cys-106) under oxidative stress. In the present study using specific antibodies against Cys-106-oxidized DJ-1 (oxDJ-1), we evaluated oxDJ-1 levels in brain and blood of PD patients. It was found that DJ-1 oxidation in erythrocytes and in the brain occurs in PD patients, particularly during the early phases. DJ-1 oxidation was effectively inhibited by endogenous antioxidant glutathione. We could develop the molecular base for the diagnosis and treatment of PD at early phases based on the levels of oxDJ-1.

Free Research Field

生化学、分子生物学

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Published: 2017-05-10  

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