Possible roles of microglia and the underlying mechanisms on the brain development

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670091
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Osaka University
• Principal Investigator: SATO Makoto 大阪大学, 連合小児発達学研究科, 教授 (10222019)
• Co-Investigator(Kenkyū-buntansha): XIE Min-Jue 福井大学, 医学部, 助教 (40444210) ; OMI Minoru 藤田保健衛生大学, 医学部, 助教 (00400416) ; IGUCHI Tokuichi 大阪大学, 医学(系)研究科(研究院), 助教 (60509305)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 神経科学 / マイクログリア / 脳・神経 / 脊髄損傷 / アルギニンメチル化酵素

Outline of Final Research Achievements

Microglia is a well-known scavenger in the brain. Several lines of evidence suggest that microglia plays a pivotal role for the brain development through its phagocytic activity. There exist two phases in the ‘activated’ microglia in terms of its scavenging activities. We here demonstrate that one type of protein arginine N-methytransferases is essential for such phase transition.

Free Research Field

解剖学