Analysis of IGF-1 receptor-independent signaling from IGF-1 and its application for drug development

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670128
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Yamaguchi University
• Principal Investigator: INUI Makoto 山口大学, 医学(系)研究科(研究院), 教授 (70223237)
• Co-Investigator(Kenkyū-buntansha): SAKAI Hiroki 山口大学, 大学院医学系研究科, 助教 (40464367)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 創傷治癒 / 細胞遊走 / インスリン様成長因子 / ペプチド / アンギオテンシン

Outline of Final Research Achievements

Growth factors including insulin-like growth factor (IGF-1) play important roles in epithelial wound healing. We previously demonstrated that the C domain of IGF-1 as well as a tetrapeptides derived from the C domain, SSSR is responsible for the promotion of keratinocyte migration and cutaneous wound healing by IGF-1. Here we studied the molecular mechanisms of the action of SSSR in keratinocytes. We demonstrated that the promotion of keratinocyte migration by SSSR or IGF-1 did not require the IGF-1 receptor but rather was mediated by signaling from angiotensin II generated by angiotensin I-converting enzyme. Our results provide new insight into the action of IGF-1 in wound healing as well as a foundation for a potential new peptide-based treatment of skin wounds.

Free Research Field

薬理学