Development of pharmacological treatment of aortic aneurysm

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670131
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General pharmacology
• Research Institution: Yokohama City University
• Principal Investigator: ISHIKAWA YOSHIHIRO 横浜市立大学, 医学(系)研究科(研究院), 教授 (40305470)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 薬理学 / 循環器・高血圧 / シグナル伝達 / 病理学 / 外科

Outline of Final Research Achievements

Many drugs that have been developed in the past decade in the cardiovascular field. However, none for treating aortic aneurisms has been developed. It is well known that chronic inflammation or atherosclerosis worsen the fragility of aorta, leading to dilatation or dissection of aorta and thus development of aortic aneurysm. The incidence of aortic aneurysm increases with age. However, surgical treatment is the only treatment choice without pharmacological therapy. From remodeling study of vessels, we have identified pharmacological treatment for suppressing aneurysm.

Free Research Field

循環器病学