Immune surveillance is involved in cardiomyocyte death in diseased hearts

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670193
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Osaka University
• Principal Investigator: FUJIO Yasushi 大阪大学, 薬学研究科(研究院), 教授 (20359839)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 心筋細胞 / 心不全 / 免疫学的監視機構 / 心筋細胞死

Outline of Final Research Achievements

Since cardiac myocytes cease to proliferate immediately after birth in mammalian hearts, cardiomyocyte death, induced by cardiovascular diseases, results in the reduction of cardiomyocytes in number, leading to cardiac dysfunction. In this context, the prevention of cardiomyocyte death is a promising therapeutic strategy against heart failure.
In this study, we have revealed that immune surveillance system is involved in cardiac cell daeth in the process of cardiac remodling after myocardial infarction. It could be proposed that immunosurvaillance system is a novel therapeutic target against heart failure.

Free Research Field

循環薬理学