2014 Fiscal Year Final Research Report
Rehabilitation of cancer cells
| Project/Area Number |
25670196
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Juntendo University |
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Principal Investigator |
HINO Okio 順天堂大学, 医学部, 教授 (90127910)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 癌 / 病理学 / 再生医療 / 遺伝子 / ips化 / Tsc遺伝子 |
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| Outline of Final Research Achievements |
Eker rats have a germline mutation in tuberous sclerosis 2 gene (Tsc2). Heterozygous mutants develop renal cell carcinomas (RCCs) within one year after birth, whereas homozygous mutants are embryonic lethal. To explore new strategies for treatment of cancer using epigenetic modification, we started studies with reprogramming of Eker rat’s cancer cells as a model case. For that, we first tried to generate Tsc2-deficient ES cells (ESCs) and embryonic fibroblast-derived iPS cells (iPSCs) from Eker rat’s, and analyzed effects of Tsc2-deficiency on pluripotency. We are characterizing them in terms of stemness and pluripotency.
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| Free Research Field |
実験病理学
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