2014 Fiscal Year Final Research Report
The study to clarify the molecular mechanism of fate decision of activated CD4 T cells
| Project/Area Number |
25670232
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OHARA Osamu 公益財団法人かずさDNA研究所, 副所長 (20370926)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 免疫 / T細胞 / 分化 / 老化 / 記憶 |
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| Outline of Final Research Achievements |
In this study, we found that Menin plays a critical role in the fate decision of activated T cells. Menin was required for the memory CD4 and CD8 T cell generation. Furthermore, TCR/IL-2-mediated activation of Menin-deficient T cells in vitro resulted in the premature cellular senescence. Menin-deficient naive CD4 T cells preferentially differentiated into Th1 and Th2 cells in vitro, whereas Th17 cell differentiation was impaired. The phenotypes observed in the Menin-deficient T cells were partially mediated by the reduced expression of Bach2. Therefore, the Menin-Bach2 pathway plays an important role in the regulation T cell-mediated immune responses.
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| Free Research Field |
免疫学
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