Development of the novel peptide restoring the tumor suppressor function for peptide-based antitumor therapeutics

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670263
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Niigata University (2014); 愛知県がんセンター(研究所) (2013)
• Principal Investigator: KONDO Eisaku 新潟大学, 医歯学系, 教授 (30252951)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ペプチド / 分子治療 / がん

Outline of Final Research Achievements

Based on the prototype peptide design, truncated form of the peptide which is enabled to restore the p14 tumor suppressor gene function was successfully obtained. The peptide could work inside the target tumor cells as a single functional form of p14-restoring sequence, by inserting the short motif which is cleaved in response to the tumor-specifically activated enzyme. The redesigned truncated p14 antitumor peptide efficiently exerted antitumor function in vitro and in vivo, which suggested to be practically available to suppress the growth of biologically aggressive tumors of the diverse origin.

Free Research Field

分子腫瘍病理学