Possible circulating permeability factors related to proteinuria in nephrotic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670269
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kanazawa University
• Principal Investigator: WADA Takashi 金沢大学, 医学系, 教授 (40334784)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 蛋白尿 / ネフローゼ症候群 / オミクス / プロテオーム / 透過性因子 / バイオマーカー

Outline of Final Research Achievements

This study was aimed to determine circulating permeability factors possibly related to proteinuria in patients with nephrotic syndrome. Permeability factors derived from circulating T and/or B cells are speculated to have a crucial role in the proteinuria of nephrotic syndrome. Circulating factors in patients with beneficial effects of reducing proteinuria by removing lymphocytes treated with lymphocytapheresis were examined using proteomic studies and bioinformatics analyses. There were several circulating factors related to the onset and relapse of nephrotic syndrome. In contrast, other circulating factors could be detected when patients achieved remission. These factors might be involved in the pathogenesis of proteinuria in patients with nephrotic syndrome.

Free Research Field

腎臓病