To assess the risk of Attention Deficit/ Hyper Activity Disorder cause by Epigenetic action and gene environment interaction.

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670291
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: Hokkaido University
• Principal Investigator: KISHI Reiko 北海道大学, 環境健康科学研究教育センター, 特任教授 (80112449)
• Co-Investigator(Kenkyū-buntansha): MUROHASHI Harumitsu 北海道大学, 大学院教育学研究院, 教授 (00182147) ; SHIRAISHI Hideaki 北海道大学, 北海道大学病院, 助教 (80374411) ; IKENO Tamiko 北海道大学, 環境健康科学研究教育センター, 特任講師 (80569715) ; MIYASHITA Chihiro 北海道大学, 環境健康科学研究教育センター, 特任講師 (70632389)
• Co-Investigator(Renkei-kenkyūsha): TOMOYUKI Hanaoka 北海道大学, 環境健康科学研究教育センター, 教授 (00228503) ; SEIKO Sasaki 北海道大学, 大学院医学研究院, 助教 (30448831)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 環境疫学 / ADHD / 喫煙曝露 / 環境遺伝交互作用 / 葉酸

Outline of Final Research Achievements

Concerning 8 year old children who participated in Hokkaido study on Environmental and Children’s health, we investigated with the Conner3P Japanese version (attention deficit hyperactivity disorder), ADHD-RS and clarified the risk of environmental factors. For example, smoking during pregnancy, taking the folic acid supplements etc. The result of the 2,545 collected questionnaires was that smoking during pregnancy increased the prevalence of the ADHD trend (OR=2.2;95%CI,1.002-4.631).
Furthermore, the ADHD -suspected group (N=138) and control group in nested case control study, the SNPs of neurotransmitter related gene （DRD4,DAT1,HTR1B,COMT,SNAP25）and brain-derived neurotrophic factor （BDNF）were investigated by EP1 system (Fludigm.com). Analyzing 200 cases have completed and 190 cases are ongoing analyzing SNPs.

Free Research Field

医歯薬学