Association of vitamin K deficiency and musculoskeletal disorders: a population-based cohort study

2015 Fiscal Year Final Research Report

• Project/Area Number: 25670293
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Epidemiology and preventive medicine
• Research Institution: National Rehabilitation Center for Persons with Disabilities (2014-2015); The University of Tokyo (2013)
• Principal Investigator: AKUNE Toru 国立障害者リハビリテーションセンター(研究所), 病院(併任研究所), 副院長 (60282662)
• Co-Investigator(Kenkyū-buntansha): YOSHIMURA Noriko 東京大学, 医学部附属病院, 特任准教授 (60240355) ; MURAKI Shigeyuki 東京大学, 医学部附属病院, 特任准教授 (40401070) ; OKA Hiroyuki 東京大学, 医学部附属病院, 特任助教 (60401064)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 医療・福祉

Outline of Final Research Achievements

We performed epidemiologic surveys in 2453 participants of Japanese population-based cohorts. Dietary vitamin K intake was assessed by a questionnaire and the percentage of dietary vitamin K intake less than 150 microgram/d was 15%. Association of dietary vitamin K intake with minimum joint space width and osteophyte area on the plain X-ray film of the knee was examined in 827 participants. A multivariate logistic regression analysis revealed that low dietary intake of vitamins K was significantly associated with minimum joint space width and osteophyte area on the knee, indices of knee osteoarthritis.

Free Research Field

整形外科学