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2014 Fiscal Year Final Research Report

Early prediction of chronic obstructive pulmonary disease prior to its onset based on cross-sectional health-related data obtained in a conventional health check-up.

Research Project

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Project/Area Number 25670325
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Hygiene and public health
Research InstitutionShowa University

Principal Investigator

NAKADATE TOSHIO  昭和大学, 医学部, 教授 (60155760)

Project Period (FY) 2013-04-01 – 2015-03-31
Keywords慢性閉塞性肺疾患 / 高感度CRP / 気道刺激症状 / 最大呼気流速
Outline of Final Research Achievements

Annual decline in forced expiratory volume in one second (dFEV1) was analyzed in 687 healthy male workers whose dFEV1 was measured over five years, in relation with various health-related cross-sectional data obtained in a conventional health check-up. As a result, cross-sectional status of serum C-reactive protein concentration, cough symptom, and maximal forced expiratory flow rate at 25 percent of forced vital capacity was associated with reduced dFEV1 independently from smoking and age.
These results suggest that inflammation, airway irritation, and air-flow limitation in peripheral lung region might be important for the early prediction of high risk population of chronic obstructive pulmonary disease prior to its onset.

Free Research Field

衛生学

URL: 

Published: 2016-06-03  

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