Inhibitory role of a hemoglobin-derived peptide hemopressin in stress pathway

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670354
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General internal medicine(including psychosomatic medicine)
• Research Institution: Kochi University
• Principal Investigator: TANAKA Kenjiro 高知大学, 教育研究部医療学系, 助教 (30552260)
• Co-Investigator(Kenkyū-buntansha): SHIMIZU Takahiro 高知大学, 教育研究部医療学系, 准教授 (00363276) ; NAKAMURA Kumiko 高知大学, 教育研究部医療学系, 技術専門職員 (30398052)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ヘモプレシン / ストレス

Outline of Final Research Achievements

This study exhibited that RVD-hemopressin, a hemoglobin-derived peptide, inhibited the activition of sympatho-adrenomedullary outflow through brain cannabinoid CB1 receptors. We also represented a possibility that spinally projecting (pre-sympathetic) hemoglobin-containing neurons of the hypothalamic paraventricular nucleus contribute to a central modulation of sympatho-adrenomedullary outflow. These findings provide basic data for the therapeutic use of RVD-hemopressin in the central regulation of stress response.

Free Research Field

神経生物学