2014 Fiscal Year Final Research Report
The possibility of pleiotropic effects of Novel Oral Anticoagulants (NOAC) on Rho-kinase-cyclophilin A System
Project/Area Number |
25670379
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Cardiovascular medicine
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Research Institution | Tohoku University |
Principal Investigator |
SHIMOKAWA Hiroaki 東北大学, 医学(系)研究科(研究院), 教授 (00235681)
|
Co-Investigator(Kenkyū-buntansha) |
SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Keywords | シグナル伝達 / スタチン / 低分子量G蛋白 |
Outline of Final Research Achievements |
We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
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Free Research Field |
医療系薬学
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