The possibility of pleiotropic effects of Novel Oral Anticoagulants (NOAC) on Rho-kinase-cyclophilin A System

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670379
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Tohoku University
• Principal Investigator: SHIMOKAWA Hiroaki 東北大学, 医学(系)研究科(研究院), 教授 (00235681)
• Co-Investigator(Kenkyū-buntansha): SATOH Kimio 東北大学, 高度教養教育・学生支援機構, 准教授 (80436120)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: シグナル伝達 / スタチン / 低分子量G蛋白

Outline of Final Research Achievements

We tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) in endothelial cells. In the present study, we demonstrated that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.

Free Research Field

医療系薬学