2014 Fiscal Year Final Research Report
Evaluation of senescence markers for lifestyle-related disease
| Project/Area Number |
25670382
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Keywords | 老化 / p53 / テロメア / p21 |
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| Outline of Final Research Achievements |
We could obtain the valid data of SNP genotyping and T/S ratio as mean LTL in 363 patients. Mean LTL was significantly longer in women than in men and inversely associated with age. Adjusted with age and sex, mean LTL had proportionately associations with total cholesterol and LDL-cholesterol levels, whereas serum creatinine level was negatively correlated with mean LTL. We identified minor alleles of FOXO1 encoding forkhead box O1 protein (rs2755213) was associated with shorter mean LTL. Analyses of patients who admitted to Niigata University Hospital showed that p53 expression was related to age and that p21 expression was significantly increased in patients with atherosclerosis. These results suggest that these molecular markers are useful for treatment of patients with lifestyle-related disease.
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| Free Research Field |
循環器内科
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