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2014 Fiscal Year Final Research Report

Role of phopholipid metabolism in the pathophysiology of renal injury

Research Project

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Project/Area Number 25670407
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Kidney internal medicine
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUGANAMI Takayoshi  東京医科歯科大学, 医歯(薬)学総合研究科, 寄附講座教授 (50343752)

Co-Investigator(Renkei-kenkyūsha) SETOU Mitsutoshi  浜松医科大学, 医学部, 教授 (20302664)
AOE Seiichiro  大妻女子大学, 家政学部, 教授 (90365049)
MORI Kiyoshi  京都大学, 大学院医学研究科, 特定准教授 (60343232)
Project Period (FY) 2013-04-01 – 2015-03-31
Keywords急性腎不全 / 質量顕微鏡 / リン脂質 / 尿細管
Outline of Final Research Achievements

Imaging mass microscope is a novel technique that is a combination of an optical microscope with a mass spectrometer, which enables us to know what kind of molecules are located in the region of interest. Kidney, which is complex anatomically and physiologically, may be a good target of imaging mass spectrometry. In this study, we induced renal ischemia-reperfusion injury as an acute kidney injury model and observed area-specific changes in quality and quantity of phosphatidylcholine. Consistently, transcriptome analysis revealed that mRNA expression of a series of enzymes of phosphatidylcholine metabolism was harmoniously regulated under these conditions. These observations suggest that imaging mass spectrometry is a powerful technology to investigate the role of local metabolic changes in response to pathophysiologic stresses.

Free Research Field

腎臓内科学

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Published: 2016-06-03  

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