Mechanisms of expansion of hematopoietic stem cell clones

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670447
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: Kanazawa University
• Principal Investigator: HIRAO Atsushi 金沢大学, がん進展制御研究所, 教授 (90343350)
• Co-Investigator(Kenkyū-buntansha): TADOKORO Yuko 金沢大学, がん進展制御研究所, 助教 (00447343)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 造血幹細胞

Outline of Final Research Achievements

It has been shown that quality of individual hematopoietic stem cells are highly variable. In this study, we analyzed functions of molecules in Ras signals in hematopoetic stem cell competition during hematopoietic reconstitution. We found that Spred1, a negative regulator of Ras/Raf/Erk, plays a critical role in dominancy of hematopoietic stem cells in a competitive assay in vivo. Further studies of Spred1-mediated control of self-renewal activity of hematopoietic stem cells would lead to deep understanding of stem cell aging and tumorigenesis.

Free Research Field

幹細胞生物学