2015 Fiscal Year Final Research Report
Development of anti-inflammatory drugs by targeting vesicular traffic in dendritic cells
| Project/Area Number |
25670460
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kagawa University (2015)
Kyoto University (2013-2014) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ISHIHAMA Yasushi 京都大学, 大学院薬学研究科, 教授 (30439244)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Keywords | 樹状細胞 |
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| Outline of Final Research Achievements |
Plasmacytoid dendritic cells (pDC) produce a vast amount of IFN-alpha by recognizing exogenous DNA through TLR9, and provoke autoimmune and inflammatory disorders. A multi-kinase inhibitor dasatinib suppresses the IFN-alpha production by pDC. To identify the responsible kinases and their substrates, we used various kinase inhibitors and mRNA knockdown, and selected 3 kinases as candidate kinases.
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| Free Research Field |
血液学、免疫学
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