Identification of host factors contributing to host intercellular translocation of Group A Streptococci which causes invasive infections

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670469
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Infectious disease medicine
• Research Institution: Kitasato University
• Principal Investigator: TAKAHASHI Takashi 北里大学, 大学院感染制御科学府, 教授 (00292855)
• Co-Investigator(Kenkyū-buntansha): ARAI Kazuaki 北里大学, 北里生命科学研究所, 研究員 (30547386)
• Co-Investigator(Renkei-kenkyūsha): MATSUI Hidenori 北里大学, 大学院感染制御科学府, 講師 (30219373) ; YOSHIDA Haruno 北里大学, 大学院感染制御科学府, 助手 (70563386)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 細菌 / 侵襲性感染症 / 細胞間透過 / ゲノム / 病原因子 / 宿主因子

Outline of Final Research Achievements

We selected high-virulent and low-virulent Group A streptococcal strains through the database concerning patients and pathogen characteristics, experiment assessing host intercellular translocation, and experiment using human CD46-transgenic mice, in order to clarify the pathological conditions of invasive streptococcal infections. As compared with those of the low-virulent strain, there were significant virulence factor (substitution of rocA gene) and host factor (up-regulation of Gstp1 gene expression), which contributed to host intercellular translocation of the high-virulent strain.

Free Research Field

感染症学、臨床微生物学、感染制御学