Investigation of HRF-mediated amplifying mechanism in food allergy

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670483
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: KASHIWAKURA Jun-ichi 独立行政法人理化学研究所, 統合生命医科学研究センター, 上級研究員 (90373290)
• Research Collaborator: KAWAKAMI Toshiaki 独立行政法人理化学研究所, 統合生命医科学研究センター, チームリーダー (60143418) ; ANDO Tomoaki 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (10724669) ; TAKEMORI TOSHITAda 独立行政法人理化学研究所, 統合生命医科学研究センター, 基盤ユニットリーダー (60114295)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: ヒスタミン遊離因子（HRF) / 食物アレルギー / マスト細胞 / HRF反応性IgE / 急速経口免疫療法(ROIT)

Outline of Final Research Achievements

Histamine-releasing factor (HRF) plays a pro-inflammatory role in IgE-dependent anaphylaxis and airway inflammation (animal model of bronchial asthma). However, it is unknown whether HRF is involved in food allergy. Here we showed that HRF inhibitor-treated mice had reduced diarrhea occurrence in allergen-sensitized mice, suggesting that HRF is required for a full inflammatory response in food allergy. HRF-reactive IgE and IgG were increased in both food allergy patients and mouse models. Levels of HRF-reactive IgG in rash oral immune tolerance-induced patients were reduced, implying that HRF-reactive IgE and IgG may serve as a new biomarker for food allergy diagnosis and evaluation.

Free Research Field

アレルギー