Simultaneous imaging of multiple bio-functions by EPR imaging method

2014 Fiscal Year Final Research Report

• Project/Area Number: 25670537
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Sapporo Medical University
• Principal Investigator: FUJII Hirotada 札幌医科大学, 医療人育成センター, 教授 (70209013)
• Co-Investigator(Renkei-kenkyūsha): AKABA Hideo 大阪大学大学院, 基礎工学研究科, 准教授 (00552077)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Keywords: 視覚化 / イメージング / EPR / ESR

Outline of Final Research Achievements

Electron Paramagnetic Resonance Imaing (EPRI) combinded with nitroxide imaging probes is known to be a powerful non-invasive method for visualizating the redox status in vivo. Recently we have improved teh conventional L-band EPR imager using the rapid-scan technique, and it becomes possible to obtain three-dimensional EPR images of small rodents. Using this improved EPR imager, simultaneous imaging of multiple bio-functions, such as redox status, oxygen concnetration, and pH, was carried out non-invasively.

Free Research Field

医歯薬学